|
KMID : 0914820070070040185
|
|
Journal of the Korean Gastric Cancer Association
2007 Volume.7 No. 4 p.185 ~ p.192
|
|
|
Expression of RUNX3 in Human Gastric Cancer
|
|
Jang Sung-Hwa
Shin Dong-Gue
Kim Il-Myung
You Byung-Ook
Yoon Jin
Park Sang-Soo
Kang Seong-Ku
Lee Yoon-Kyung
Heo Su-Hak
Cho Ik-Hang
|
|
|
Abstract
|
|
|
Purpose: RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer. In the present study, we
examined the pattern of RUNX3 expression in gastric cancer cells from gastric cancer specimens and the impact of its alteration on clinical outcome.
Materials and Methods:: A total of 124 samples of both gastric cancer and normal tissue were obtained from 124
patients who underwent curative gastrectomy at the Seoul Medical Center from January 2001 to December 2005. RUNX3 expression was determined by immunohistochemical staining, and the results were analyzed. Statistical analysis wabased on clinicopathological findings and differences in survival rates.
Results: The mean age of the patients was 61 years, and the male:female ratio was 1.9:1. The expression rate
of RUNX3 was 59.7% (74/124). The expression rate was higher in differentiated gastric cancers (nucleus: 9.1%, cytoplasm: 57.6%) than in the undifferentiated types (nucleus: 5.2%, cytoplasm: 46.6%) (P=0.133). The 5-year survival rates according to RUNX3 expression determined from cancer tissue were 88.9% for the nucleus ± cytoplasm(+) group of patients, 76.1% for the cytoplasm only (+) group of patients, and 65.3% for the RUNX3 negative expression group of patients (P=0.626). Only UICC TNM staging showed statistical significance related to the survival rate, as determined by multivariate analysis.
Conclusions: The RUNX3 expression rate was higher in differentiated gastric cancer than in the undifferentiated types without significance. Although RUNX3 expression predicted better survival, based on multivariate analysis, the finding was not statistically significant. More cases should be further evaluated.
|
|
|
KEYWORD
|
|
|
Gastric cancer, Prognosis, RUNX3
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|
|